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  • Title: Inhibitory effect of ethanol on endothelium-dependent vascular responsiveness.
    Author: Hatake K, Wakabayashi I, Kakishita E, Taniguchi T, Ouchi H, Sakaki N, Hishida S.
    Journal: Eur J Pharmacol; 1989 Sep 22; 168(3):277-83. PubMed ID: 2511033.
    Abstract:
    The effect of ethanol was studied on the endothelium-dependent vascular responses in isolated rat aortic strips. Ethanol depressed the endothelium-dependent relaxation induced by acetylcholine and ATP but not that induced by the calcium ionophore, A23187. Endothelium-independent relaxation in response to sodium nitroprusside, a soluble guanylate cyclase activator, was not depressed by ethanol. On the other hand, ethanol significantly enhanced the contractile response to clonidine, an alpha 2-adrenoceptor agonist, in endothelium-intact strips and depressed it in endothelium-denuded strips. These results suggest that ethanol can inhibit endothelium-dependent relaxation by acting on endothelial cells but not on smooth muscle cells, and can also suppress an inhibitory effect of the endothelium on alpha 2-adrenoceptor-mediated vasoconstriction.
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