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  • Title: [The effects of hypocapnia and hypercapnia on tissue surface PO2 in hemorrhaged dogs].
    Author: Hashimoto K, Okazaki K, Okutsu Y.
    Journal: Masui; 1989 Oct; 38(10):1271-4. PubMed ID: 2511354.
    Abstract:
    To investigate the effects of carbon dioxide on the local blood flow during hemorrhagic shock, the tissue surface PO2 of liver, kidney and femoral muscle was measured during normocapnia, hypocapnia and hypercapnia. Eight adult mongrel dogs were anesthetized with pentobarbital, intubated and ventilated mechanically with 100% oxygen to maintain normocapnia. After laparotomy, miniature clark-type polarographic oxygen electrodes were placed on the surface of the liver, kidney and femoral muscle. The animals were hemorrhaged via arterial catheter to a mean arterial blood pressure of 50mmHg. The hypocapnia was produced by increasing respiratory rate and the hypercapnia was induced by adding the exogenous carbon dioxide. Hypocapnia decreased the liver and kidney surface PO2, and increased the muscle surface PO2. On the contrary, hypercapnia increased the liver and kidney surface PO2 and decreased the muscle surface PO2. So, it is possible that hypocapnia may compromise the oxygenation of the liver and kidney in the hemorrhagic shock.
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