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  • Title: PI3K, MAPK EPK1/2 and p38 are involved in the realization of growth potential of mesenchymal progenitor cells under the influence of basic fibroblast growth factor.
    Author: Zyuz'kov GN, Danilets MG, Ligacheva AA, Zhdanov VV, Udut EV, Miroshnichenko LA, Simanina EV, Chaikovskii AV, Trofimova ES, Minakova MY, Udut VV, Dygai AM.
    Journal: Bull Exp Biol Med; 2014 Aug; 157(4):436-9. PubMed ID: 25113604.
    Abstract:
    We studied PI3K, MAPK/EPK1/2 and p38-dependent signaling cascade under stimulation of the functions of mesenchymal progenitor cells by fibroblast growth factor. The important role of PI3K and EPK1/2 in the realization of their growth potential has been revealed. Experiments have demonstrated a blocking effect of PI3K inhibitor on proliferation and differentiation of progenitor cells and EPK1/2 inhibitor on mitotic activity of the progenitor cells. The p38-mediated MAPK pathway did not play a role in determining the proliferative and differentiation status of fibroblast CFU.
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