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  • Title: An efficient rose bengal based nanoplatform for photodynamic therapy.
    Author: Gianotti E, Martins Estevão B, Cucinotta F, Hioka N, Rizzi M, Renò F, Marchese L.
    Journal: Chemistry; 2014 Aug 25; 20(35):10921-5. PubMed ID: 25116185.
    Abstract:
    Organically modified mesoporous silica nanoparticles (MSNs) containing rose bengal (RB), a xanthene dye, were successfully synthesized. RB-modified MSNs have shown a relevant photostability and a high efficiency in the photoproduction and delivery of singlet oxygen ((1)O2), which is particularly promising for photodynamic therapy (PDT) applications. In vitro tests have evidenced that RB-MSNs are able to reduce cell proliferation in one of the most aggressive skin cancer types (SK-MEL-28) after green-light irradiation.
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