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  • Title: Impact of nonlethal levels of Metacid-50 and carbaryl on thyroid function and cholinergic system of Channa punctatus.
    Author: Ghosh P, Bhattacharya S, Bhattacharya S.
    Journal: Biomed Environ Sci; 1989 Jun; 2(2):92-7. PubMed ID: 2511899.
    Abstract:
    With regard to brain acetylcholinesterase and acetylcholine and serum triiodothyronine (T3) and thyroxine (T4) profiles, a biphasic response pattern was elicited in Channa punctatus chronically exposed to nonlethal doses of locally used pesticides, namely, Metacid-50 and Carbaryl. Data revealed that these xenobiotics caused significant inhibition of brain acetylcholinesterase activity and a decrease in thyroxine level accompanied by a concurrent increase in acetylcholine accumulation and T3 level. It is surmised that Metacid-50 and Carbaryl influence both neural and hormonal functions.
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