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  • Title: DNA replication and poly(ADP-ribosyl)ation of chromatin.
    Author: Anachkova B, Russev G, Poirier GG.
    Journal: Cytobios; 1989; 58(236):19-28. PubMed ID: 2512056.
    Abstract:
    The role of poly(ADP-ribosyl)ation in chromatin replication and the activity of poly(ADP-ribose) synthetase in the newly synthesized and old chromatin was studied. It was found that 3-aminobenzamide, which is an inhibitor of poly(ADP-ribose) synthetase, had no effect on the initiation of DNA synthesis and only a moderate effect on DNA chain elongation. However, poly(ADP-ribose) synthetase activity in the newly replicated chromatin was two to three times higher than that of the unreplicated chromatin.
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