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  • Title: Clinical Manifestations and Outcomes of Syphilis-associated Uveitis in Northern Spain.
    Author: Fonollosa A, Martinez-Indart L, Artaraz J, Martinez-Berriotxoa A, Agirrebengoa K, Garcia M, Lopez-Soria L, Sorribas M, Diaz-Valle D, Blanco R, Rueda-Gotor J, Adan A, Llorenç V, Cordero-Coma M, Distefano L, Segura A, Blanco A.
    Journal: Ocul Immunol Inflamm; 2016; 24(2):147-52. PubMed ID: 25121345.
    Abstract:
    PURPOSE: To describe the clinical characteristics and to assess visual prognosis of patients with syphilis-associated uveitis in northern Spain. METHODS: Retrospective review of clinical records in eight general uveitis referral centers. RESULTS: Since the year 2000, 50 patients have been diagnosed: 31 men and 19 women; median age was 41 (19-76) years. A total of 34% were co-infected with HIV and 24% presented systemic manifestations of syphilis. Median initial visual acuity and vision at last visit in 93 affected eyes was 20/50 (20/20-20/2000) and 20/22 (20/20-20/2000), respectively (p < .0001). The most frequent manifestation was papillitis (33.3%). Fifty percent of eyes with macular edema on admission presented worsening of visual acuity at last visit, whereas frequency of worsening in eyes without edema was 7.1% (p = 0.009). CONCLUSIONS: In our series, patients with syphilitic uveitis were more usually middle-aged men and were frequently co-infected with HIV. Although most patients showed posterior segment involvement, visual prognosis was good.
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