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  • Title: Phorbaketals L-N, cytotoxic sesterterpenoids isolated from the marine sponge of the genus Phorbas.
    Author: Lee Y, Wang W, Kim H, Giri AG, Won DH, Hahn D, Baek KR, Lee J, Yang I, Choi H, Nam SJ, Kang H.
    Journal: Bioorg Med Chem Lett; 2014 Sep 01; 24(17):4095-8. PubMed ID: 25124114.
    Abstract:
    Three new sesterterpenoids, phorbaketals L-N (1-3), were isolated from a marine sponge of the genus Phorbas and their complete structures were elucidated via analysis of HRFABMS and NMR spectroscopic data. Phorbaketal N (3) showed potent cytotoxicity against human pancreas cancer cells (IC50=11.4 μM).
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