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  • Title: MiR-150-5p suppresses colorectal cancer cell migration and invasion through targeting MUC4.
    Author: Wang WH, Chen J, Zhao F, Zhang BR, Yu HS, Jin HY, Dai JH.
    Journal: Asian Pac J Cancer Prev; 2014; 15(15):6269-73. PubMed ID: 25124610.
    Abstract:
    Growing evidence suggests that miR-150-5p has an important role in regulating genesis of various types of cancer. However, the roles and the underlying mechanisms of miR-150-5p in development of colorectal cancer (CRC) remain largely unknown. Transwell chambers were used to analyze effects on cell migration and invasion by miR-150-5p. Quantitative real-time PCR (qRT-PCR), Western blotting and dual-luciferase 3' UTR reporter assay were carried out to identify the target genes of miR-150-5p. In our research, miR-150-5p suppressed CRC cell migration and invasion, and MUC4 was identified as a direct target gene. Its effects were partly blocked by re-expression of MUC4. In conclusiomn, miR-150-5p may suppress CRC metastasis through directly targeting MUC4, highlighting its potential as a novel agent for the treatment of CRC metastasis.
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