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Pubmed for Handhelds

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  • Title: A new series of HAPs as anti-HBV agents targeting at capsid assembly.
    Author: Yang XY, Xu XQ, Guan H, Wang LL, Wu Q, Zhao GM, Li S.
    Journal: Bioorg Med Chem Lett; 2014 Sep 01; 24(17):4247-9. PubMed ID: 25127104.
    Abstract:
    A series of novel Heteroaryldihydropyrimidines (HAPs) derivatives were designed and synthesized as potent inhibitors of HBV capsid assembly. These compounds were prepared from efforts to optimize an earlier series of HAPs, and compounds Mo1, Mo7, Mo8, Mo10, Mo12, and Mo13 demonstrated potent inhibition of HBV DNA replication at submicromolar range.
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