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  • Title: Fe-catalyzed direct dithioacetalization of aldehydes with 2-chloro-1,3-dithiane.
    Author: Lai J, Du W, Tian L, Zhao C, She X, Tang S.
    Journal: Org Lett; 2014 Sep 05; 16(17):4396-9. PubMed ID: 25133872.
    Abstract:
    Present methods to synthesize 1,3-dithiane molecules require either harsh reaction conditions or highly specialized reagents. We have developed a catalytic dithioacetalization process that directly gains access to the corresponding 1,3-dithianes using aldehydes and 2-chloro-1,3-dithiane in a highly efficient manner. This methodology is beneficial due to mildness of the reaction conditions, and the dithioacetaliation process results in good to excellent yields by using 15 mol % of an iron catalyst.
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