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  • Title: In vivo imaging of the mouse retina using high-resolution optical coherence tomography.
    Author: Machalińska A, Lejkowska R, Duchnik M, Rogińska D, Kawa M, Wiszniewska B.
    Journal: Klin Oczna; 2014; 116(1):11-5. PubMed ID: 25137914.
    Abstract:
    PURPOSE: In this study, we demonstrate the advantages of high-resolution optical coherence tomography for the non-invasive, in vivo, three-dimensional imaging of the mouse retina. METHODS: High-resolution optical coherence tomography images of the mouse retina were acquired using the Bioptigen Envisu R2200-HR SD-OCT system. We measured the retinal thickness and compared the measurements to those obtained using conventional histology techniques. RESULTS: High-resolution spectral-domain optical coherence tomography enables high-quality in vivo visualization of retinal structures in mice, providing an accurate quantitative description of retinal layers. Additionally, the ultra-high-speed system offers many advantages over histology, e.g., it permits the visualization of retinal microvasculature and pulsatile flow dynamics. CONCLUSIONS: Spectral domain optical coherence tomography is a new important tool for the in vivo analysis of mouse eyes.
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