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  • Title: [Hemodynamic vertebrobasilar insufficiency demonstrated by chronic oligemic cerebral flow and cerebellar ataxia: two new concepts].
    Author: Trouillas P, Philippon B, Nighoghossian N.
    Journal: C R Acad Sci III; 1989; 309(20):755-62. PubMed ID: 2514012.
    Abstract:
    We propose in the paper of the concept of nuclear hemodynamic vertebrobasilar insufficiency, defined as an oligemic blood flow lower than 35 ml/100 g/min. in the brain stem-cerebellum zone, when using the method of inhalation of 133Xe. In 15 patients, the neurophysiologic manifestations included intermittent symptoms. We describe here permanent neurophysiologic motor disturbances: extrapyramidal Dopa sensitive syndrome (2/15), chronic cerebellar ataxia (12/15), often associated with cerebellar atrophy (8/12). The concept of chronic oligemic cerebellar ataxia, corresponding to selective neuronal death and/or neurochemical failure, is proposed.
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