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  • Title: Synthesis and aldose reductase-inhibitory activity of benzo[b]furan derivatives possessing a carboxymethylsulfamoyl group.
    Author: Ohishi Y, Mukai T, Nagahara M, Yajima M, Kajikawa N.
    Journal: Chem Pharm Bull (Tokyo); 1989 Sep; 37(9):2398-405. PubMed ID: 2514045.
    Abstract:
    Various benzo[b]furan derivatives with a carboxymethylsulfamoyl group were prepared and evaluated for aldose reductase-inhibitory potency. Most of the compounds displayed significant inhibitory activities (IC50, 10(-8)-10(-7) M). Among the test compounds, the compounds having a carboxymethylsulfamoyl group at the 3- or 4-position exhibited the greatest inhibitory potency. Structure-activity trends of the tested compounds are discussed.
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