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  • Title: Smoking exerts unfavourable effect on human gastroduodenal mucosal endogenous prostacyclin-level.
    Author: Balint GA.
    Journal: East Afr Med J; 1989 Aug; 66(8):535-7. PubMed ID: 2514079.
    Abstract:
    It seems that endogenous prostacyclin is one of the most important natural protective substances in the (human) gastroduodenal mucosa. According to the observations, in humans there is a definite tendency toward decreased endogenous prostacyclin production in the gastroduodenal mucosa of smokers. This phenomenon draws attention to the possible role of smoking in the development of peptic ulcer disease.
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