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  • Title: Synergism between sodium chloride and sodium taurocholate and development of pepsinogen-altered pyloric glands: relevance to a medium-term bioassay system for gastric carcinogens and promoters in rats.
    Author: Tatematsu M, Mutai M, Inoue K, Ozaki K, Furihata C, Ito N.
    Journal: Jpn J Cancer Res; 1989 Nov; 80(11):1035-40. PubMed ID: 2514164.
    Abstract:
    In an approach to early detection of gastric carcinogens and promoters in an in vivo test system, promotion by sodium chloride (NaCl) and the synergistic effects of NaCl and sodium taurocholate (Na-TC) on development of pepsinogen-altered pyloric glands (PAPG) in rat glandular stomach after initiation with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were investigated. A total of 205 male WKY/NCrj rats were divided into 8 groups. Group 1 was given a single dose of MNNG of 160 mg/kg body weight by gastric intubation, and starting 2 weeks later basal diet containing Na-TC for 18 weeks. In addition, 1 ml doses of saturated NaCl solution were given by gastric intubation at weeks 4, 6, 8 and 10. Similarly, group 2 was treated with MNNG and Na-TC, while group 3 animals received MNNG and NaCl. Group 4 was given MNNG alone. Groups 5-8 served as equivalent controls without MNNG initiation. The results revealed significantly enhanced induction of immunohistochemically defined PAPG in the Na-TC + NaCl (P less than 0.001), Na-TC (P less than 0.01) and NaCl (P less than 0.01) treated animals initiated with MNNG. Sodium chloride demonstrated a clear synergistic effect with Na-TC in promoting the development of PAPG, suggesting possible advantage for its use in medium-term in vivo assays for detection of gastric carcinogens and promoters.
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