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  • Title: [Effectiveness of cicletanine on lesions in spontaneously hypertensive rats. Curative study--dose-effect relationship].
    Author: Droy-Lefaix MT, Ruchoux MM, Berthet P, Bakri F, Bosquet D, Narcisse G, Guillemain G.
    Journal: Arch Mal Coeur Vaiss; 1989 Nov; 82 Spec No 4():163-8. PubMed ID: 2514659.
    Abstract:
    Genetically hypertensive rats receiving a high sodium content diet develop, within weeks of their birth, major alterations of tissues and blood vessels. The purpose of this study was to evaluate the effects of cicletanine, a synthetic antihypertensive drug, on the progress of genetic hypertension. Iffa Credo SHR-SP male rats aged 11 weeks were divided into 4 groups. One group was used as control and 3 groups were treated with oral cicletanine in doses of 10, 30 and 90 mg/kg/day respectively. The control group showed a high mortality rate due to a significant decrease of weight gain and a highly significant increase of blood pressure, these changes being associated with lesions of tissues and vessels in the brain, heart and kidneys. A curative treatment with cicletanine improved these parameters and was accompanied by good tissue preservation. The curative effect of cicletanine seems to be due to an increase in endogenous prostaglandin synthesis.
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