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  • Title: [Effect of cicletanine on prostacyclin generation in vivo].
    Author: Bourgain RH, Deby C, Andries R.
    Journal: Arch Mal Coeur Vaiss; 1989 Nov; 82 Spec No 4():33-6. PubMed ID: 2514665.
    Abstract:
    The administration of arachidonic acid to live rabbits if followed by the generation of prostacyclin and/or thromboxane. Cicletanine increased the production of prostacyclin in a first group of rabbits and amplified the prostacyclin/thromboxane ratio in a second group of the thromboxane type. The most probable mechanism for this action is activation of prostacyclin synthase by cicletanine. This was confirmed in the in vivo model by a study of the platelet-vascular wall interaction: tranylcyprominE, a prostacyclin synthase inhibitor, increased the interaction. Under these experimental conditions, cicletanine inhibited the effect of tranylcypromine and completely restored the enzymatic activity of prostacyclin synthase.
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