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  • Title: A double-blind, controlled study of high-dose L-deprenyl in the treatment of Parkinson's disease.
    Author: Frankel JP, Kempster PA, Stibe CM, Eatough VM, Nathanson M, Lees AJ, Stern GM.
    Journal: Clin Neuropharmacol; 1989 Oct; 12(5):448-51. PubMed ID: 2514981.
    Abstract:
    The conventional dose of deprenyl used in Parkinson's disease is 10 mg/day, having been established by in vitro platelet studies and clinical evaluation. Twelve patients with Parkinson's disease on treatment with L-dopa who showed evidence of wearing-off effects or motor oscillation were studied in a double-blind, placebo-controlled, crossover trial to compare conventional doses of deprenyl with higher doses (up to 40 mg/day) and placebo. We did not find higher doses of deprenyl to be superior to conventional doses and in 17% of cases treatment had to be withdrawn because of side effects.
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