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  • Title: Synthesis and evaluation of 4-anilinoquinazoline bioisosteres as potential anti-breast cancer agents.
    Author: El-Ansary AK, Kamal AM, Al-Ghorafi MA.
    Journal: Eur J Med Chem; 2014 Oct 30; 86():202-10. PubMed ID: 25151582.
    Abstract:
    Based on one of the four major categories of scaffold hopping theory namely hetrocycle replacements, a series of 5-arylthieno[2,3-d]pyrimidines had been prepared and evaluated as anti-breast cancer agents. Optimization by combination of different pharmacophores with the thienopyrimidine scaffold led to discovery of biologically active compounds.
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