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  • Title: Differential effects of parenteral nutrition on tumor growth and erythrocyte polyamine levels in the rat.
    Author: Grossie VB, Nishioka K, Chang TH, Patenia D, Benitez MM, Ajani JA, Ota DM.
    Journal: JPEN J Parenter Enteral Nutr; 1989; 13(6):590-5. PubMed ID: 2515305.
    Abstract:
    The influence of total parenteral nutrition (TPN) on tumor growth and erythrocyte polyamine levels was evaluated in rats with a transplantable fibrosarcoma or a Ward colon tumor. During the experimental periods the fibrosarcoma grows exponentially when rats are fed chow ad libitum while the colon tumor reaches a plateau of its Gompertzian growth curve. A 12-day regimen of TPN resulted in an increased growth of the colon tumor but not the fibrosarcoma. The erythrocyte putrescine levels of fibrosarcoma-bearing rats and the levels of putrescine, spermidine, and spermine of Ward colon-tumor-bearing rats were significantly increased by TPN compared with similarly treated nontumor-bearing (NTB) rats. When the growth of the fibrosarcoma was slowed by feeding a restricted intake (RI) regimen, a subsequent 6-day regimen of TPN resulted in increased tumor growth. Erythrocyte polyamine levels of fibrosarcoma-bearing, RI-rats were elevated by TPN repletion. There was a consistent, significant, interaction between TPN and tumor presence on the erythrocyte putrescine levels in fibrosarcoma-bearing rats and the levels of all polyamines in Ward colon-tumor-bearing rats. The effects of TPN on tumor growth and erythrocyte polyamine levels of tumor-bearing rats may be dependent on the growth characteristics of the tumor. The data demonstrate that TPN consistently enhanced the tumor contribution to the erythrocyte putrescine pool.
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