These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Excitotoxicity of NMDA and kainic acid is modulated by nigrostriatal dopaminergic fibres.
    Author: Chapman AG, Dürmuller N, Lees GJ, Meldrum BS.
    Journal: Neurosci Lett; 1989 Dec 15; 107(1-3):256-60. PubMed ID: 2515501.
    Abstract:
    The excitotoxic action of N-methyl-D-aspartate (NMDA) and of kinase (KA) has been assessed by measuring glutamic acid decarboxylase (GAD) and choline acetyltransferase (ChAT) activity in the rat striatum 5 days after focal microinjections of NMDA or KA. Prior unilateral lesioning of the nigrostriatal dopaminergic pathway by focal injection of 6-hydroxydopamine decreases the excitotoxic effect of NMDA and of KA.
    [Abstract] [Full Text] [Related] [New Search]