These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Elucidation of a role of plasma albumin during collagen-induced aggregation of bovine platelets.
    Author: Sekiya F, Takagi J, Saito Y.
    Journal: Thromb Res; 1989 Nov 01; 56(3):407-15. PubMed ID: 2515611.
    Abstract:
    Bovine platelets of which phospholipids were labeled with [14C] arachidonate were stimulated by collagen. Omitting albumin in suspending medium suppressed aggregation and arachidonate liberation from phospholipids. Analysis of [14C] arachidonate metabolites released into medium revealed that release of 12S-hydroxyeicosatetraenoic acid (12-HETE) from stimulated platelets was dependent on the existence of albumin, while thromboxane B2 release was not. Moreover, exogenously added 12-HETE inhibited collagen-induced aggregation. These observations suggest that albumin potentiates aggregation by preventing intracellular accumulation of 12-HETE, and strengthen our previous finding that albumin in plasma is very essential for collagen-induced aggregation of platelets (Sekiya, F., Takagi, J., Kasahara, K., Inada, Y. and Saito, Y. (1988) Thrombos. Res. 50, 837-846.).
    [Abstract] [Full Text] [Related] [New Search]