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  • Title: Azide phosphoramidite in direct synthesis of azide-modified oligonucleotides.
    Author: Fomich MA, Kvach MV, Navakouski MJ, Weise C, Baranovsky AV, Korshun VA, Shmanai VV.
    Journal: Org Lett; 2014 Sep 05; 16(17):4590-3. PubMed ID: 25156193.
    Abstract:
    Azide and phosphoramidite functions were found to be compatible within one molecule and stable for months in solution kept frozen at -20 °C. An azide-carrying phosphoramidite was used for direct introduction of multiple azide modifications into synthetic oligonucleotides. A series of azide-containing oligonucleotides were modified further using click reactions with alkynes.
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