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  • Title: Inflammasome activation and metabolic disease progression.
    Author: Li HB, Jin C, Chen Y, Flavell RA.
    Journal: Cytokine Growth Factor Rev; 2014 Dec; 25(6):699-706. PubMed ID: 25156419.
    Abstract:
    Innate pattern recognition receptors NLRs are cytosolic sensors that detect endogenous metabolic stress and form a multiprotein complex called the inflammasome, that recruits and activates caspase enzymes mediating the activation of the cytokines IL-1β and IL-18. The innate immune system and metabolic system are evolutionarily conserved, intimately integrated, and functionally dependent. In recent decades, obesity-associated metabolic diseases have been become a worldwide epidemic. Here we review recent evidence that demonstrates the important roles of NLRs and inflammasomes in response to metabolic stress in different tissues.
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