These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Diazepam induces abnormal mitosis in the early Drosophila embryo.
    Author: Callaini G, Dallai R, Riparbelli MG.
    Journal: Biol Cell; 1989; 67(3):313-20. PubMed ID: 2515902.
    Abstract:
    Drosophila embryos, because of their high proportion of dividing nuclei, offer many advantages for the study of the mitotic cycle. In the present study we combined immunofluorescence with interference contrast techniques to follow centrosome and spindle behavior in embryos exposed to diazepam during the first stages of development. Exposure to 100 micrograms/ml of diazepam produced polyploid and aneuploid figures resulting from the unusual fusion of one or more adjacent spindles. Diazepam also causes the inhibition of centrosome shifting and induces the formation of monopolar spindles during the metaphase-anaphase transition.
    [Abstract] [Full Text] [Related] [New Search]