These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Actions of a newly synthesized nitro-compound, E-4701, on rabbit vascular smooth muscles.
    Author: Satoh S, Fujiwara T, Nishiye E, Sumimoto K, Itoh T, Suzuki H, Kuriyama H.
    Journal: Jpn J Pharmacol; 1989 Nov; 51(3):357-68. PubMed ID: 2516167.
    Abstract:
    The effects of a newly synthesized water soluble and light resistant nitro-compound, E-4701, on the electrical and mechanical properties of smooth muscle cells of rabbit mesenteric and coronary arteries were investigated. In the endothelium-denuded rabbit mesenteric artery, E-4701 relaxed the tissue pre-contracted by noradrenaline (IC50 = 40 microM) to a greater extent than that contracted by high K, but to a lesser extent than that contracted by acetylcholine (ACh) or high K in endothelium-denuded rabbit coronary artery (the IC50 was 20 nM or 60 nM, respectively). Nitroglycerin showed much the same relaxing action on the above tissue (IC50 for the ACh- or K-induced contraction was 20 nM or 65 nM, respectively). Relaxing actions of E-4701 or nitroglycerin were prevented by 10 microM methylene blue. In muscle cells of the porcine coronary artery, E-4701 or nitroglycerin inhibited the Ca-transient provoked by ACh, as examined using fura-2. Both drugs had no effect on the Ca-induced contraction in skinned muscle strips. ACh produced a transient hyperpolarization with subsequent depolarization, but in the endothelium-denuded tissues. ACh only depolarized the membrane. E-4701 inhibited the ACh-induced depolarization, but nitroglycerin did not. We concluded from our observations that E-4701 has the typical characteristics of a nitrocompound with an inhibitory action on the agonist-induced membrane depolarization.
    [Abstract] [Full Text] [Related] [New Search]