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  • Title: MIC gene polymorphism and haplotype diversity in Zhuang nationality of Southern China.
    Author: Chen E, Lin L, Chen CJ, Zhang XY, Luo QZ, Yu P.
    Journal: Hum Immunol; 2014 Sep; 75(9):953-9. PubMed ID: 25167773.
    Abstract:
    Zhuang ethnic minority is the largest minority group in China. Here, we report for the first time the polymorphisms of MICA and MICB in a healthy Zhuang population of 209 unrelated individuals. Using polymerase chain reaction-sequence specific priming (PCR-SSP) and sequencing-based typing (PCR-SBT), 13 MICA-sequence alleles and 5 MICA-STR alleles, as well as 11 MICB alleles were detected, among which MICA(∗)010, MICA(∗)A5 and MICB(∗)005:02 were the most frequent alleles. Linkage disequilibria was investigated and the most common two-locus haplotypes were MICB(∗)005:02-MICA(∗)010 and MICB(∗)014-MICA(∗)045. These results suggest informative genetic markers for investigating origins and evolution of MHC class I region haplotypes in Zhuang population.
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