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  • Title: Simultaneous determination of rivaroxaban and dabigatran levels in human plasma by high-performance liquid chromatography-tandem mass spectrometry.
    Author: Korostelev M, Bihan K, Ferreol L, Tissot N, Hulot JS, Funck-Brentano C, Zahr N.
    Journal: J Pharm Biomed Anal; 2014 Nov; 100():230-235. PubMed ID: 25173108.
    Abstract:
    A sensitive and accurate liquid chromatography method with mass spectrometry detection was developed and validated for the quantification of dabigatran (Pradaxa(®)) and rivaroxaban (Xarelto(®)). (13)C6-dabigatran and (13)C6-rivaroxaban were used as the internal standard. A single-step protein precipitation was used for plasma sample preparation. This method was validated with respect to linearity, selectivity, inter- and intra-day precision and accuracy, limit of quantification and stability. The lower limit of quantification was 2.5ng/mL for both drugs in plasma.
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