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  • Title: Production of epoxygenase metabolite by human reproductive tissues.
    Author: Patel L, Sullivan MH, Elder MG.
    Journal: Prostaglandins; 1989 Dec; 38(6):615-24. PubMed ID: 2517348.
    Abstract:
    Human amnion, trophoblast and umbilical vein endothelial cells synthesise an arachidonic acid metabolite which is neither a lipoxygenase nor a cyclo-oxygenase product. It is sensitive to stimulants and inhibitors of the cytochrome-P450-dependent epoxygenase system and co-migrates on HPLC with 14,15-epoxyeicosatrienoic acid (14,15-EET), which is an epoxygenase product. The function of 14,15-EET in these reproductive tissues is unknown, but it may be involved in the maintenance of vascular function.
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