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  • Title: [Using mixture design to optimize preparation technology of gankeshuangqing dispersible tablets].
    Author: Zhang F, Han L, Zhang DK, Zhang C, Yang M, Bao AY, Xiao X.
    Journal: Zhong Yao Cai; 2014 Mar; 37(3):499-503. PubMed ID: 25174118.
    Abstract:
    OBJECTIVE: To study the preparation process and the best prescription of Gankeshuangqing dispersible tablets. METHODS: In order to select the prescription of Gankeshuangqing dispersible tablets and determine the dissolution, the disintegration time was used as index, single factor method and mixture design were used. RESULTS: The compositions of Gankeshuangqing dispersible tablets prescription were 50% baicalin, 12.5% andrographolide, CaSO4 23.5%, micro-silica gel 4.1%, and L-HPC 11.3%. The disintegration time was (47 +/- 1) s. Dissolution tests showed that the dissolution rate of this product was higher than that of Gankeshuangqing capsules. CONCLUSION: The developed Gankeshuangqing dispersible tablets embodies the characteristics of dispersible tablets. The prescription is reasonable and the technology is feasible.
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