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  • Title: Effect of cyclosporin A on carbohydrate metabolism of isolated rat liver cells.
    Author: Riegel W, Stephan E, Balle C, Schollmeyer P, Heidland A, Hörl WH.
    Journal: Kidney Int Suppl; 1989 Nov; 27():S236-8. PubMed ID: 2517674.
    Abstract:
    Treatment with cyclosporin A may cause hyperglycemia. The mechanisms for this phenomenon are not entirely clear. The effect of cyclosporin A treatment on rat liver phosphoenolpyruvate-carboxykinase and hepatocyte glycogen synthetase and phosphorylase activity was therefore investigated. Glycogen synthetase (total enzyme activity and the active I-form) was elevated in hepatocytes of rats undergoing immunosuppressive treatment with cyclosporin A. Glycogen phosphorylase activity showed no difference compared to hepatocytes from control rats. Activity of phosphoenolpyruvate-carboxykinase in liver homogenates was significantly enhanced after cyclosporin A treatment. Thus, it appears that cyclosporin A treatment stimulates gluconeogenesis, and glucose is used as substrate for glycogen synthesis in vitro. Differences of in vitro and in vivo experiments might be explained by long-term induction of phosphoenolpyruvate-carboxykinase and the short-term effects of cyclosporin A on glycogen synthetase.
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