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  • Title: Clinical significance of combined antinuclear and anticytoplasmic antibodies detected by immunofluorescence.
    Author: Lee TK, Rothberger H.
    Journal: Chin Med J (Engl); 1989 Dec; 102(12):911-5. PubMed ID: 2517735.
    Abstract:
    Anti-nuclear antibodies (ANA) combined with anti-cytoplasmic antibodies (ACA) in 0.6% (n = 43) of 7,121 consecutive patients referred for ANA screening were observed. Homogeneous/cytoplasmic was the most frequently combined ANA/ACA pattern among 6 different indirect immunofluorescent (IF) combinations. Distribution of diseases was similar in patients with ANA/ACA and those controls with ANA alone. However, the ANA/ACA results were often transitory, especially in systemic lupus erythromatosus (SLE). The appearance of transitory ANA/ACA combinations on serial ANA testing may be useful as a serologic marker for SLE.
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