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  • Title: Treatment of hyaline membrane disease by human amniotic fluid surfactant.
    Author: Jin HZ, Chen C, Jin QL, Shao XM.
    Journal: Chin Med J (Engl); 1989 Dec; 102(12):944-6. PubMed ID: 2517741.
    Abstract:
    A case of hyaline membrane disease was treated successfully with pulmonary surfactant (PS) isolated from human amniotic fluid. Dosage was 150 mg phospholipid/kg. The exogenous surfactant was instilled into the airway via a tracheal cannula. Clinical symptoms, PO2 and FiO2 improved evidently 24 hours after administration. L/S ratio and phosphatidylglycerol recovered gradually in aspirates. Lung X-ray film manifested "white lung" before instillation of surfactant and showed a striking improvement 3 days after treatment. The duration of mechanical ventilation was 6 days. During the period of recovery complications of patent ductus arteriosus and bacterial pneumonia developed. However, the patient recovered completely and was discharged 32 days after admission.
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