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  • Title: Antibacterial synergy of glycerol monolaurate and aminoglycosides in Staphylococcus aureus biofilms.
    Author: Hess DJ, Henry-Stanley MJ, Wells CL.
    Journal: Antimicrob Agents Chemother; 2014 Nov; 58(11):6970-3. PubMed ID: 25182634.
    Abstract:
    Glycerol monolaurate (GML) is a natural surfactant with antimicrobial properties. At ∼0.3 mM, both GML and its component lauric acid were bactericidal for antibiotic-resistant Staphylococcus aureus biofilms. With the use of MICs of antibiotics obtained from planktonic cells, GML and lauric acid acted synergistically with gentamicin and streptomycin, but not ampicillin or vancomycin, to eliminate detectable viable biofilm bacteria. Images of GML-treated biofilms suggested that GML may facilitate antibiotic interaction with matrix-embedded bacteria.
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