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  • Title: An ultrasensitive label-free electrochemical biosensor for microRNA-21 detection based on a 2'-O-methyl modified DNAzyme and duplex-specific nuclease assisted target recycling.
    Author: Zhang X, Wu D, Liu Z, Cai S, Zhao Y, Chen M, Xia Y, Li C, Zhang J, Chen J.
    Journal: Chem Commun (Camb); 2014 Oct 21; 50(82):12375-7. PubMed ID: 25187259.
    Abstract:
    Based on a highly efficient 2'-O-methyl modified G-quadruplex-hemin DNAzyme and duplex-specific nuclease (DSN) assisted target recycling, a novel label-free electrochemical biosensor for microRNA-21 (miR-21) detection is developed here. By employing the strategy, this DNA biosensor can detect as low as 8 aM miR-21 and exhibits high discrimination ability even against a single-base mismatch.
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