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  • Title: Isolation of α-glucosidase inhibitors including a new flavonol glycoside from Dendrobium devonianum.
    Author: Sun J, Zhang F, Yang M, Zhang J, Chen L, Zhan R, Li L, Chen Y.
    Journal: Nat Prod Res; 2014; 28(21):1900-5. PubMed ID: 25189122.
    Abstract:
    From the whole plant of Dendrobium devonianum, a new flavonol glycoside, 5-hydroxy-3-methoxy-flavone-7-O-[β-D-apiosyl-(1 → 6)]-β-D-glucoside, as well as 13 known compounds, was isolated. Their structures were identified based on extensive spectroscopic studies including HR-EI-MS, (1)H, (13)C NMR, DEPT, H-H COSY, HSQC, HMBC and NOESY spectra. The new compound and gigantol were evaluated for their α-glucosidase inhibitory activity, and both displayed more potent α-glucosidase inhibitory activity than acarbose, one of the most potent α-glucosidase inhibitor drugs, with the inhibition rate of 43.4% and 36.7%, respectively, in the concentration of 437.5 μmol/L.
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