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  • Title: Effect of RBC concentrate transfusions on serum ferritin content in children with acute leukaemia.
    Author: Bebeshko VG, Bruslova EM, Tsvietkova NM, Iatsemirskii SM, Puchkareva TI, Gonchar LA, Krukovska VV, Zelinska AV, Mishchenko LP.
    Journal: Probl Radiac Med Radiobiol; 2013; (18):173-9. PubMed ID: 25191722.
    Abstract:
    OBJECTIVE: To study the serum ferritin levels in children with acute leukemia, depending on the number of transfusions of RBC concentrate and period of disease. MATERIALS AND METHODS: We studied the red blood count, serum iron and ferritin levels in 54 patients with acute leukemia before chemotherapy, at the time of a standardized treatment protocol, and after transfusions of RBC concentrates. RESULTS: In the debute of acute leukemia just before treatment lauch the serum ferritin in 81.5% of children was 2.3-2.5 higher than normal. The need for transfusion of RBC concentrates was higher under serum ferritin level exceeding 500 ng/mL. The association was established between ferritin content and age of the children, variant of acute leukemia and period of the disease. CONCLUSIONS: The level of serum ferritin can be used as a marker of ferrokinetic status for timely diagnosis of iron overload in children with acute leukemias and for application of treatment-and-prophylactic actions. Meta – vyvchyty vmist syrovatkovogo ferytynu u ditej z gostrymy lejkemijamy zalezhno vid chysla transfuzij koncentrativ erytrocytiv krovi ta periodu zahvorjuvannja. Materialy i metody. Vyvchaly pokaznyky erytrocytarnoi' lanky krovi, vmist syrovatkovogo zaliza ta ferytynu u 54 hvoryh na gostri lejkemii' do pochatku polihimioterapii', v period provedennja standartyzovanogo protokolu likuvannja ta pislja transfuzij koncentrativ erytrocytiv krovi. Rezul'taty. V debjuti gostryh lejkemij do likuvannja u 81,5% ditej vmist ferytynu v syrovatci krovi buv v 2,3-2,5 razy vyshhe normatyvnogo. Potreba v transfuzijah koncentrativ erytrocytiv u hvoryh bula bil'shoju pry koncentracii' ferytynu v syrovatci krovi vyshhoju za 500 ng/ml. Vstanovlena zalezhnist' rivnja ferytynu vid viku ditej, variantu gostroi' lejkemii' ta periodu zahvorjuvannja. Vysnovky. Riven' syrovatkovogo ferytynu mozhe vykorystovuvatys' v jakosti markeru stanu ferokinetychnyh procesiv v organizmi dlja svojechasnoi' diagnostyky nadlyshku zaliza u ditej z gostrymy lejkemijamy ta zastosuvannja likuval'no-profilaktychnyh zahodiv.
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