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  • Title: Role of VEGF-A gene in the formation of late effects after the Chornobyl accident.
    Author: Ilyenko IM.
    Journal: Probl Radiac Med Radiobiol; 2013; (18):190-9. PubMed ID: 25191724.
    Abstract:
    OBJECTIVE: To characterize the VEGF-A gene expression and its main effects on immune cells in the Chornobyl NPP accident clean-up workers. MATERIALS AND METHODS: VEGF-A gene expression and its main effects on immune cells were studied in 55 persons by a real-time PCR analysis and immunophenotyping of immune competent cells. RESULTS: Disorders of regulation of neoangiogenesis were found in remote period upon radiation exposure. Elevated levels of VEGF-A gene expression correlated with TP53 gene expression in the ChNPP accident clean-up workers. Correlation was established between the percentage of the immunoregulatory T-cell subpopulations and VEGF-A expressing in the group of exposed persons and there was demonstrated a suppression of specific immune response of CD4⁻8⁺ T cells. Correlation between the percentage of CD4⁺25⁺ cells and radiation dose in a group of Chornobyl clean-up workers is not related to VEGF-A expression, so this type of immune response can be regarded as a manifestation of long-term effects after exposure. CONCLUSIONS: Some parameters were identified characterizing the state and abnormalities of the "immunity-angio-genesis" system. Those parameters could be promising in prediction of neoplastic process in remote period upon radiation exposure. Meta. Oharakteryzuvaty osoblyvosti ekspresii' gena VEGF-A ta jogo osnovni efekty vidnosno klityn imunnoi' systemy uchasnykiv likvidacii' naslidkiv avarii' (ULNA) na ChAES. Materialy i metody. Provedeno ocinka zminy rivnja ekspresii' gena VEGF-A u lejkocytah peryferychnoi' krovi 55 osib metodom polimeraznoi' lancjugovoi' reakcii' u real'nomu chasi ta imunofenotypuvannja imunokompetentnyh klityn. Rezul'taty. Vstanovleni porushennja u reguljacii' neoangiogenezu u viddalenomu periodi pislja oprominennja. Vyznacheno pidvyshhenyj riven' ekspresii' gena VEGF-A, shho koreljuje z ekspresijeju gena TR53 u grupi ULNA na ChAES. Vstanovlenyj zvjazok mizh vidsotkom imunoreguljatornyh subpopuljacij T-klityn ta ekspresijeju VEGF-A v grupi oprominenyh osib ta prodemonstrovano prygnichennja specyfichnoi' imunnoi' vidpovidi CD4-8+ T-klityn. Vstanovleno koreljacijnu zalezhnist' mizh vidsotkom CD4+25+ klityn ta dozoju oprominennja u grupi ULNA na ChAES, jaka ne povjazana z ekspresijeju VEGF-A, shho daje pidstavy oharakteryzuvaty takyj typ imunologichnogo reaguvannja jak projav viddalenyh efektiv pislja oprominennja. Vysnovky. Vyznacheno rjad pokaznykiv, jaki harakteryzujut' stan ta porushennja u systemi „imunitet-angiogenez” ta mozhut' buty perspektyvnymy u prognozuvanni puhlynnogo procesu u viddalenomu periodi pislja oprominennja.
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