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  • Title: Influence of adverse drug events on morbidity and mortality in intensive care units: the JADE study.
    Author: Ohta Y, Sakuma M, Koike K, Bates DW, Morimoto T.
    Journal: Int J Qual Health Care; 2014 Dec; 26(6):573-8. PubMed ID: 25192926.
    Abstract:
    OBJECTIVE: To identify the influence of adverse drug events (ADEs) on morbidity and mortality in intensive care units (ICUs). DESIGN: A prospective cohort study. SETTING: ICU setting at three acute care hospitals in Japan. PARTICIPANTS: All patients aged ≥15 years were admitted to all ICUs during a 6-month study period. INTERVENTION: No intervention. MAIN OUTCOME MEASURES: Mortality in the ICUs and the length of the ICU stay. . RESULTS: We included 459 patients with a total of 3231 patient-days. Ninety-nine ADEs occurred in 70 patients (15%), so that the incidence of ADEs was 30.6 per 1000 patient-days and 21.6 ADEs per 100 admissions. Seventy-three patients (16%) died during their ICU stay. Excluding 38 deaths within 3 days after admission, 12 patients (17%) died among the 70 patients who had at least one ADE during their ICU stay and 23 (7%) died among 351 without an ADE (P = 0.003). The median ICU length of stay was 3 days. Excluding 73 patients who died during their ICU stay, the median ICU stay of patients with at least one ADE was 13 days, while it was only 2 days in the remainder (P < 0.0001). ADEs were associated with longer length of ICU stay but not with mortality even after adjusting for patients' severity of illness. CONCLUSIONS: ADEs were common in ICUs and significantly associated with longer length of ICU stay but did not influence on mortality.
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