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  • Title: [Cephalosporins: bacterial resistance measured by penicillin-binding proteins].
    Author: Garrido J, López F.
    Journal: Rev Med Chil; 1989 Sep; 117(9):1037-43. PubMed ID: 2519470.
    Abstract:
    Antibacterial potency of cephalosporins depends on inhibition (acylation) of one or more penicillin-binding proteins (PBP). Recently, reduced affinity of PBP for cephalosporins and other B-lactam agents has been found in some cases. Mechanism for these changes in affinity are analyzed in this review.
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