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  • Title: Modeling nucleotide excision repair and its impact on UV-induced mutagenesis during SOS-response in bacterial cells.
    Author: Bugay AN, Krasavin EA, Parkhomenko AY, Vasilyeva MA.
    Journal: J Theor Biol; 2015 Jan 07; 364():7-20. PubMed ID: 25195002.
    Abstract:
    A model of the UV-induced mutation process in Escherichia coli bacteria has been developed taking into account the whole sequence of molecular events starting from initial photo-damage and finishing with the fixation of point mutations. The wild-type phenotype bacterial cells are compared with UV-sensitive repair-deficient mutant cells. Attention is mainly paid to excision repair system functioning as regards induced mutagenesis.
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