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  • Title: Photoactive Ru(II) complexes with dioxinophenanthroline ligands are potent cytotoxic agents.
    Author: Hidayatullah AN, Wachter E, Heidary DK, Parkin S, Glazer EC.
    Journal: Inorg Chem; 2014 Oct 06; 53(19):10030-2. PubMed ID: 25198057.
    Abstract:
    Two novel strained ruthenium(II) polypyridyl complexes containing a 2,3-dihydro-1,4-dioxino[2,3-f]-1,10-phenanthroline (dop) ligand selectively ejected a methylated ligand when irradiated with >400 nm light. The best compound exhibited a 1880-fold increase in cytotoxicity in human cancer cells upon light-activation and was 19-fold more potent than the well-known chemotherapeutic, cisplatin.
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