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  • Title: Effects of methoxy substituents on the glutathione peroxidase-like activity of cyclic seleninate esters.
    Author: Press DJ, McNeil NM, Hambrook M, Back TG.
    Journal: J Org Chem; 2014 Oct 03; 79(19):9394-401. PubMed ID: 25198287.
    Abstract:
    Cyclic seleninate esters function as mimetics of the antioxidant enzyme glutathione peroxidase and catalyze the reduction of hydrogen peroxide with a stoichiometric thiol. While a single electron-donating methoxy substituent para to the selenium atom enhances the catalytic activity, m-methoxy groups have little effect and o-methoxy substituents suppress activity. The effects of multiple methoxy groups are not cumulative. This behavior can be rationalized by opposing mesomeric and steric effects. Oxidation of the product disulfide via its thiolsulfinate was also observed.
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