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  • Title: Antitumor activity of orally administered streptococcal preparation, OK-432 on murine solid tumors and its absorption from the gut.
    Author: Nio Y, Shiraishi T, Tsuchitani T, Tobe T, Sugawara Y, Saito M, Kamiyama H.
    Journal: In Vivo; 1989; 3(5):307-13. PubMed ID: 2519870.
    Abstract:
    OK-432 is an immunopotentiator which is normally administered by injection. In the present study, the antitumor activity of orally administered OK-432 on various solid tumors and the absorption of OK-432 from the gut were studied. Orally administered OK-432 inhibited the growth of Meth-A and BAMC-1 fibrosarcomas which had been subcutaneously transplanted in BALB/c mice. Autoradiograms of mice which had been administered 14C-labelled OK-432 orally demonstrated the absorption of OK-432 from the gut, and about 6% of orally administered OK-432 was absorbed 24 hrs after its administration. Moreover, an immunofluorescent study using an anti-OK-432 antibody revealed specific fluorescence in the mesenteric lymph node of mice which had been orally administered with OK-432. These results suggest that oral administration of OK-432 may be a beneficial immunotherapy.
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