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  • Title: Modification of the behavioural effects of amineptine after acute, subacute and chronic administration of phenobarbital in mice.
    Author: De Angelis L.
    Journal: In Vivo; 1989; 3(5):331-4. PubMed ID: 2519874.
    Abstract:
    In an open-field test, mice that were given an acute treatment with 20 mg/kg ip phenobarbital and/or 10-20 mg/kg ip amineptine showed an increase in locomotor activity and rearing. Tolerance to the subacute or chronic effects of phenobarbital, but not to those of amineptine, was found. After subacute or chronic treatment with phenobarbital in association with amineptine, a significant decrease in the stimulating effect of amineptine was observed, as compared to single or associated acute treatments. These data demonstrate that, after subacute or chronic administration of phenobarbital and amineptine, an interaction occurs, and they outline the importance of enzyme induction in the metabolism of amineptine.
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