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  • Title: Micronized progesterone reduces vasoconstriction in the placenta.
    Author: Miller NR, Dolinsky BM, Napolitano PG.
    Journal: J Matern Fetal Neonatal Med; 2015 Sep; 28(13):1581-4. PubMed ID: 25204334.
    Abstract:
    OBJECTIVE: To investigate if micronized progesterone (P4) has the ability to attenuate thromboxane mimetic U46619-mediated fetoplacental artery vasoconstriction. METHODS: Paired cotyledons obtained from the same placenta of five-term subjects were analyzed. The fetal artery and maternal intervillous space of one cotyledon was infused with P4 while another cotyledon was infused with control perfusate. After 30 min, a bolus dose of U44619 was administered to both cotyledons. RESULTS: The change in the measured fetoplacental vascular pressure caused by bolus administration of U46619 was less in the cotyledons infused with P4 (p = 0.009). CONCLUSION: Continuous treatment with P4 significantly attenuates the U46619-mediated fetoplacental vasoconstriction.
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