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  • Title: [Characteristics of lipid peroxidation and activity of sympathetic nervous system in patients with chronic calculous pyelonephritis].
    Author: Oskolkov SA, Zhmurov VA, Tverdoĭ VE, Arshakian GG, Zhmurov DV, Siniaev EA.
    Journal: Urologiia; 2014; (3):8-12. PubMed ID: 25211919.
    Abstract:
    108 patients (89 women and 19 men) aged from 18 to 59 years with chronic pyelonephritis (CP) on the background of urolithiasis in a phase of active inflammation were evaluated. Along with the standard methods of examination, survey plan included the use of specific biochemical diagnostic methods. The latter included an evaluation of lipid peroxidation, the level of fat-soluble antioxidant alpha-tocopherol, fractions of phospholipids and cholesterol in the membranes of polymorphonuclear leukocytes (PMN). As a result of examination, The changes in the activity of lipid peroxidation and structure of the lipid phase of PMN membranes were identified. There was an increase in urinary excretion of catecholamines (epinephrine and norepinephrine), which indirectly indicates an increase in the activity of sympathetic nervous system contributing to the progression of CP.
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