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  • Title: Radioimmunoassay for brain natriuretic peptide (BNP) detection of BNP in canine brain.
    Author: Itoh H, Nakao K, Saito Y, Yamada T, Shirakami G, Mukoyama M, Arai H, Hosoda K, Suga S, Minamino N.
    Journal: Biochem Biophys Res Commun; 1989 Jan 16; 158(1):120-8. PubMed ID: 2521447.
    Abstract:
    We established a highly sensitive and specific radioimmunoassay (RIA) for BNP. Our RIA detected BNP-like immunoreactivity (-LI) in the porcine and canine brains but did not detect BNP-LI in the human, monkey or rat brain. The widespread distribution of BNP-LI was demonstrated both in the porcine and canine brains, with the highest concentration in the medulla oblongata. In contrast, the highest concentration of ANP-LI determined simultaneously was in the midbrain and the olfactory bulb. High performance-gel permeation chromatography coupled with RIA revealed that the major component of BNP-LI was eluted at the position of synthetic BNP with a small molecular weight (3K). These results indicate that the RIA for BNP serves as a useful tool to investigate physiological roles of BNP.
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