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  • Title: [Clopheline-induced aggression in mice: role of genotype and the dopaminergic system].
    Author: Nikulina EM, Klimek V, Popova NK.
    Journal: Biull Eksp Biol Med; 1989 Jan; 107(1):47-9. PubMed ID: 2521565.
    Abstract:
    Clophelin (CLO) in a dose 10 mg/kg induced aggressive behaviour in mice significantly dependent of genotype. Pretreatment with flupentixol and haloperidol inhibited or blocked CLO-evoked aggression in high-aggressive mice. Apomorphine administered with CLO enhanced aggression in low-aggressive mice. Stimulation of D2 receptors by bromocriptine failed to change CLO-induced aggression. It was suggested that dopamine system was involved in CLO-aggression through D1 receptors.
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